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Emerging roles of podoplanin in vascular development and homeostasis
Yanfang Pan,Lijun Xia
Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 421-430 doi: 10.1007/s11684-015-0424-9
Keywords: podoplanin CLEC-2 Prox1 O-glycosylation lymphatic vascular development and maintenance lymphoidorgan homeostasis
Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells
Sumedha Roy, Yuan Zhuang
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 374-386 doi: 10.1007/s11684-018-0652-x
A family of transcription factors known as Id proteins, or inhibitor of DNA binding and differentiation, is capable of regulating cell proliferation, survival and differentiation, and is often upregulated in multiple types of tumors. Due to their ability to promote self-renewal, Id proteins have been considered as oncogenes, and potential therapeutic targets in cancer models. On the contrary, certain Id proteins are reported to act as tumor suppressors in the development of Burkitt’s lymphoma in humans, and hepatosplenic and innate-like T cell lymphomas in mice. The contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumor outcomes are still not well understood. In this review, we explore the roles of Id proteins in lymphocyte development and tumorigenesis, particularly with respect to inhibition of their canonical DNA binding partners known as E proteins. Transcriptional regulation by E proteins, and their antagonism by Id proteins, act as gatekeepers to ensure appropriate lymphocyte development at key checkpoints. We re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor development. These mechanistic insights can allow better appreciation of the context-dependent roles of Id proteins in cancers and improve considerations for therapy.
Keywords: Id proteins lymphoma leukemia T cells B cells tumor suppressor oncogene
Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao
Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 468-477 doi: 10.1007/s11684-015-0419-6
Mature T-cell lymphoid malignancies comprise a group of heterogeneous diseases that vary in clinicopathologicalBone marrow (BM) infiltration is more commonly present in mature T-cell lymphoid malignancies comparedstudy, clinical characteristics and prognostic factors were analyzed in 225 patients with mature T-cell lymphoidclinical characteristics may be useful in more effectively stratifying patients with mature T-cell lymphoid
Keywords: mature T-cell lymphoid malignancies clonal T-cell population bone marrow infiltration prognostic factors
Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang
Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 288-303 doi: 10.1007/s11684-015-0412-0
Keywords: TLR MyD88 hematopoiesis bone marrow failure leukemia myelodysplastic syndrome
Zinc homeostasis in the metabolic syndrome and diabetes
Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai
Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 31-52 doi: 10.1007/s11684-013-0251-9
Zinc (Zn) is an essential mineral that is required for various cellular functions. Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabetic complications. The associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem from the multiple roles of Zn: (1) a constructive component of many important enzymes or proteins, (2) a requirement for insulin storage and secretion, (3) a direct or indirect antioxidant action, and (4) an insulin-like action. However, whether there is a clear cause-and-effect relationship of Zn with metabolic syndrome, diabetes, or diabetic complications remains unclear. In fact, it is known that Zn deficiency is a common phenomenon in diabetic patients. Chronic low intake of Zn was associated with the increased risk of diabetes and diabetes also impairs Zn metabolism. Theoretically Zn supplementation should prevent the metabolic syndrome, diabetes, and diabetic complications; however, limited available data are not always supportive of the above notion. Therefore, this review has tried to summarize these pieces of available information, possible mechanisms by which Zn prevents the metabolic syndrome, diabetes, and diabetic complications. In the final part, what are the current issues for Zn supplementation were also discussed.
Keywords: zinc zinc transporters metallothionein diabetes diabetic complications insulin resistance antioxidant
Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu
Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 108-115 doi: 10.1007/s11684-019-0730-8
Keywords: post-transplantation cyclophosphamide allogeneic hematopoietic stem cell transplantation lymphoid malignancies
Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 460-471 doi: 10.1007/s11684-021-0861-6
Keywords: low-carbohydrate diet obesity nonalcoholic fatty liver disease continuous glucose monitoring mean sensor glucose
Frontiers of Medicine doi: 10.1007/s11684-023-0983-0
Keywords: mitochondrial fission Ca Berberine alleviates myocardial murine model HFpEF
Zfyve16 regulates the proliferation of B-lymphoid cells
Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren
Frontiers of Medicine 2018, Volume 12, Issue 5, Pages 559-565 doi: 10.1007/s11684-017-0562-3
Keywords: Zfyve16 endofin hematopoiesis TGF-β lymphocytes
Planetary Homeostasis of Reactive Nitrogen Through Anaerobic Ammonium Oxidation
Guibing Zhu,Bangrui Lan,Shuci Liu,Cameron M. Callbeck,Shanyun Wang,Liping Jiang,Asheesh Kumar Yadav,Jan Vymazal,Mike S. M. Jetten,Ganlin Zhang,Yongguan Zhu,
Engineering doi: 10.1016/j.eng.2023.09.013
Keywords: biogeochemical N-cycle oxic–anoxic interface nature-based solution biogeoengineering nitrogen sustainable development
Engineered Vasculature for Organ-on-a-Chip Systems Review
Abdellah Aazmi, Hongzhao Zhou, Yuting Li, Mengfei Yu, Xiaobin Xu, Yutong Wu, Liang Ma, Bin Zhang, Huayong Yang
Engineering 2022, Volume 9, Issue 2, Pages 131-147 doi: 10.1016/j.eng.2021.06.020
Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurateThe circulatory system, the most abundant organ in the human body, plays a crucial role in oxygen exchangeThus, it is essential to integrate the circulatory system into an organ-on-a-chip to recreate tissueand organ microenvironments and physiological functions.This review discusses the synergy between the vasculature and the emerging organ-on-a-chip technology
Keywords: Organ-on-a-chip Vasculature Bioprinting Tumor-on-a-chip
A literature review of perishable medical resource management
Frontiers of Engineering Management Pages 710-726 doi: 10.1007/s42524-023-0278-9
Keywords: perishable medical resources organ transplant healthcare products decision analytics operations management
ECRG4: a new potential target in precision medicine
Xin Qin, Ping Zhang
Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 540-546 doi: 10.1007/s11684-018-0637-9
Keywords: ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis
Piezoelectric pump with flexible venous valves for active cell transmission
Frontiers of Mechanical Engineering 2022, Volume 17, Issue 4, doi: 10.1007/s11465-022-0712-4
Keywords: venous valve flexible venous valve cell transmission organ-on-a-chip system piezoelectric device
The relevance of James Lovelock’s research and philosophy to environmental science and academia
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1639-7
Keywords: independence Climate change Electron capture detector Environmental equilibrium Global warming Homeostasis
Title Author Date Type Operation
Emerging roles of podoplanin in vascular development and homeostasis
Yanfang Pan,Lijun Xia
Journal Article
Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells
Sumedha Roy, Yuan Zhuang
Journal Article
Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies:
Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao
Journal Article
Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases
Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang
Journal Article
Zinc homeostasis in the metabolic syndrome and diabetes
Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai
Journal Article
post-transplantation cyclophosphamide for allogeneic peripheral stem cell transplantation for adult patients with lymphoid
Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu
Journal Article
Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized
Journal Article
alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis
Journal Article
Zfyve16 regulates the proliferation of B-lymphoid cells
Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren
Journal Article
Planetary Homeostasis of Reactive Nitrogen Through Anaerobic Ammonium Oxidation
Guibing Zhu,Bangrui Lan,Shuci Liu,Cameron M. Callbeck,Shanyun Wang,Liping Jiang,Asheesh Kumar Yadav,Jan Vymazal,Mike S. M. Jetten,Ganlin Zhang,Yongguan Zhu,
Journal Article
Engineered Vasculature for Organ-on-a-Chip Systems
Abdellah Aazmi, Hongzhao Zhou, Yuting Li, Mengfei Yu, Xiaobin Xu, Yutong Wu, Liang Ma, Bin Zhang, Huayong Yang
Journal Article